Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2018-2019)

Rapid diagnosis of human disease at the patient point-of-care is key to timely and effective treatment. Thisx000D
research project will explore the extent to which an advanced spectroscopic technique, known asx000D
surface-enhanced Raman spectroscopy (SERS) can be used to render a simple rapid vertical flow assay into ax000D
much more powerful quantitative test. A quantitative rapid vertical flow assay, which this project seeks tox000D
demonstrate, would allow for earlier detection of human disease, and would allow for improved health carex000D
monitoring (such as in determination of HIV viral load, etc). All of this would still be possible at the patientx000D
point-of-care, which would ensure rapid and effective disease treatment. Our recent Engage project is comingx000D
to an end, and we have made excellent progress on this front. Improved limit-of-detection and increasedx000D
selectivity have been illustrated, as well as guidelines for the production of stable and reproducible goldx000D
colloids conjugated with both the capture agent and the Raman-active label. However, there is still much workx000D
to do, including pushing the limit of detection further through the exploration of other shapes / sizes ofx000D
particles, as well as testing in biologically relevant matrices (i.e. serum). In addition, a robust data analyticsx000D
approach is needed to advance the technology forward.