Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019).

The grant proposal consists in establishing a method to locate and characterize the binding pockets of smallx000D
molecule ligands (so called fragments) onto a protein target, at atomic resolution. NMX Research andx000D
Solutions Inc. is a research organization specialized in drug discovery and fragment screening using nuclearx000D
magnetic resonance spectroscopy. The company aims at developing novel methods for the screening ofx000D
fragment and small molecule onto proteins. Such challenging project requires highly sensitive biophysicalx000D
methods to obtain high-resolution structural information. Hence, understanding how low-affinity fragmentsx000D
bind to proteins remains a fundamental question and a technical challenge raised by NMX Research andx000D
Solutions. Dr. Calmettes, expert in protein structures and X-ray crystallography, will develop for NMXx000D
Research and Solutions an alternative method to identify and locate low-affinity fragment-binding sites onx000D
proteins using protein X-ray crystallography. Only a few groups in Canada have the expertise in preparing,x000D
crystallizing, and solving protein structures. This project is highly relevant for the Canadian industry and thex000D
advancement of knowledge in Canada; it is anticipated to open new avenues for the design of protein regulatorx000D
for a variety of applications in biotechnology, bioscience and bio-industrial sectors in Canada.