Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021)

As the average age of the population of Canada and the developed world rises,x000D
neurodegenerative conditions will become increasingly prevalent and a growing burden onx000D
the healthcare system and economy. A major neurodegenerative disease is Alzheimersx000D
disease (AD), which causes memory and cognition loss. AD and dementia affect roughly 1.1x000D
million Canadians and incur an economic cost of $10.4B per year in Canada. Currently, therex000D
is no cure or effective treatment. The Lancet Neurology Commission recently stated, anx000D
effective therapy for AD is perhaps the greatest unmet need facing modern medicine."x000D
This project addresses the challenge of understanding neuron circuits in the brain involved inx000D
memory, with the goal of improving the efficacy of neurostimulation therapies for AD andx000D
dementia. Such treatments would stimulate specific brain circuits to promote memoryx000D
encoding and/or retrieval in patients with AD or dementia. The project will create a new typex000D
of wireless, implantable deep brain probes for rodent experiments on memory loss rescuex000D
that uses optical stimulation and electrical stimulation+recording of specific groups ofx000D
neurons. Importantly, these brain probes will be made using the same processes andx000D
infrastructure as semiconductor microelectronics to ensure compatibility with volumex000D
manufacturing and a viable technology translation path that will widely benefit neuroscientistsx000D
and clinical researchers.x000D
This project brings together world-class expertise from around the globe in photonics,x000D
electronics, neuroscience, and deep brain stimulation. In addition to the Canadian teamx000D
members, the project involves collaborators in France and United States who will providex000D
complementary expertise in the design, fabrication, and testing of the neural probes. Thex000D
results of this international project will benefit the health of Canadians and lead to high-valuex000D
neurotechnology products that are designed and integrated in Canada.