Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021)

In Radiotherapy, dosimetry and treatment planning are highly advanced for ionizing radiation.x000D
Radiation dose is accurately defined and the relationship between it andx000D
clinical response is well understood. For photodynamic therapy (PDT), the definition of PDTx000D
dose is unclear and how it correlates with clinical response has yet to be precisely defined.x000D
Present-day clinical protocols for PDT of non-melenoma skin cancer (NMSC) are relativelyx000D
straight-forward: a photosensitizer is administered, a period of time elapses before shiningx000D
light and then light with a specific fluence rate illuminates the patient. The same protocol isx000D
applied to an entire patient population and as a result, PDT of NMSC is conducted withoutx000D
detailed customized planning that takes into account patient to patient variability as practicedx000D
in radiotherapy. Our research goal is to work on in vivo measurement of optical properties andx000D
functional parameters such as oxygen levels together with measuring the temporal andx000D
spatial photosensitizer concentration uptake. With these quantitative metrics, the hope is thatx000D
we will be able to model and predict the response of individual patients to PDT.. Betterx000D
dosimetry will advance the development and utilization of PDT similar to radiation therapyx000D
where the field is very quantitative and evidence-based. Ultimately patient-specific planning ofx000D
PDT treatment will increase NMSC clinical outcomes.