Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019).

With its high incidence rate (1 in 7 men), prostate cancer is the second leading cause of cancer death in men inx000D
North America. Towards this end, high-dose-rate (HDR) brachytherapy offers the ability to treat prostatex000D
cancer with a dose-modulated approach for optimized clinical performance, while avoiding sensitive zones thatx000D
might interfere with the patient's well-being. The industrial partner, Elekta Ltd, is specialized in radiotherapyx000D
and radioactive brachytherapy systems used for focal treatments in patients with breast, lung, liver or prostatex000D
cancer. A key advantage of the technology developed by Elekta is the integration of pre-operative imaging tox000D
create a dose-plan and treat the tumor based on the patient's MRI, adapting the dose modulation during thex000D
treatment phase. However a major limitation in the widespread use of HDR brachytherapy resides in thex000D
involuntary movement or local deformation of the prostate gland during the intervention. Indeed, thesex000D
radiotherapy systems depend on accurate tracking of the tumor during radiation treatment, which can be highlyx000D
influenced bu the deformation of the prostate. This can cause possible toxicity of local therapy to surroundingx000D
tissue and increase the risk of local persistence or recurrence. The goal of this project is to develop ax000D
computerized tool which will measure the deformation induced in the prostate based on computer vision andx000D
machine learning approaches, ultimately compensating the deformation during image-guided treatments. Thisx000D
project will have the following objectives: (1) Create an interface to load the pre-operative (MRI) andx000D
intra-operative acquisitions (3D ultrasound or MRI); (2) Implement a 3D shape modelling tool of the prostate;x000D
(3) Compute a 4D deformation field, by developing a prostate registration algorithm using a non-parametricx000D
diffeomorphic approach; (4) Clinical validation to verify prostate deformation between pre-operative andx000D
intra-operative acquisitions. A major impact of this work will be to enable tissue deformation analysis in anx000D
interventional environment for precise dose-painting in combination with multiparametric MR imaging,x000D
potentially reducing recurrence and minimizing the risk that normal prostate is excessively irradiated.