Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019).

Coccidiosis is a parasitic condition of broiler chickens. The lesions casued by coccidia are a pre-disposingx000D
factor for necrotic enteritis, an ailment that is associated with world wide economic losses to poultry producersx000D
of > $6 billion annually. In conventional production, coccidiosis and necrotic enteritis are prevented andx000D
managed through anti-coccidial and antibiotic administration. However the use of antibiotics are prohibitedx000D
during the bird's life in raised without antibiotic (RWA) feeding programs. In RWA production, coccidiosis canx000D
be prevented through vaccination, yet not without risk. Vaccines contain live parasites, which replicate ax000D
number of times through the intestines, damaging the organ in the process. Damage to the intestine results inx000D
inflammation and reductions in markers of gut integrity that have been linked to decreases in weight gainx000D
following vaccination. Feed additives that promote proper intestinal functioning may prove beneficial inx000D
mitigating the intestinal damage induced by live vaccines. Selko Elarom Poultry (ElrM), produced by Trouwx000D
Nutrition, is a synergistic blend of phenolic compounds, short and medium chain fatty acids, and organic acids.x000D
Previous in-house studies completed by Trouw Nutrition have demonstrated that ElrM improves feedx000D
conversion ratio, an index of growth supporting the use of Elarom in RWA applications. However, thex000D
mechanistic underpinnings of these effects have not been elucidated. This is an important question to address,x000D
as it will provide further empirical evidence to support the use of Selko Elarom Poultry and reduce thex000D
economic impact of Coccidiosis and vaccination against it. Therefore the problem the company would like tox000D
investigate, and the objective of the proposed work is to examine the effects of Elarom on indices of intestinalx000D
inflammation and gut integrity in broiler chickens. Trouw Nutrition does not have the expertise to answer thisx000D
question and has subsequently partnered with Dr. Wright, an expert in this area. The work in this proposal willx000D
provide important insight into the mechanisms of action of ElrM and will be an important step in expandingx000D
the use of ElrM in other species.