Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019).

This project aims to identify a family of molecules that can generally bind to conserved binding pockets inx000D
epigenetic proteins. These molecules (called bioisosteres) would be generally useful starting points forx000D
epigenetic drug development efforts, as well as valuable tools for basic research into epigenetic modulators.x000D
ChemRoutes has a family of scaffold molecules - called ChemCores - that are potentially well suited to bind tox000D
epigenetic methyl reader pockets. The Hof lab at UVic are world leaders in the development of biochemicalx000D
assays for binding to such proteins. The proposal is first to establish a panel of fluorescence polarization assaysx000D
for five distinct methyl reader proteins, and then to run three series of proprietary compounds prepared byx000D
ChemRoutes through the panel of assays. The project will identify novel bioisosteres that ChemRoutes will bex000D
able to leverage in further research efforts and partnerships towards epigenetic modulation.