Subventions et des contributions :

Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019).

A Toronto-based company, Rna Diagnostics, has developed a test that determines whether chemotherapy isx000D
working. The test is based upon the level of RNA disruption in a tumour sample, and its computationalx000D
analysis. RNA is copied from DNA, and increased RNA can help to cause tumour growth in cancer. RNAx000D
decay is a signal that chemotherapy is working and that tumour cells are dying. However, Rna Diagnosticsx000D
would like to understand the pathways that cause RNA decay, and whether different levels of RNA disruptionx000D
mean different drug effects or outcome.Dr. Sarah Sabatinos (Ryerson University, Toronto) will use yeast cellsx000D
to test how RNA disruption happens after drug treatment. The Sabatinos lab will use microscopy to understandx000D
how RNA disruption happens, and test whether additional marks of chemotherapy effectiveness are present.x000D
Our combined goal is to make Rna Diagnostics' tool better able to predict tumour cell death, and work earlierx000D
after drug is given. This work is important to promote training and improve diagnostics and predictivex000D
computational tools in Canada.